Ayako Makino Selected Research

Stromal Interaction Molecule 2

1/2020	Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels.
1/2018	STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension.

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Ayako Makino Research Topics

Disease

18	Pulmonary Hypertension 12/2021 - 11/2009
13	Hypoxia (Hypoxemia) 12/2021 - 08/2012
9	Vascular Remodeling 01/2022 - 07/2011
9	Pulmonary Arterial Hypertension 07/2020 - 07/2011
6	Familial Primary Pulmonary Hypertension 01/2021 - 07/2011
4	Type 2 Diabetes Mellitus (MODY) 11/2021 - 01/2018
3	Vascular Diseases (Vascular Disease) 01/2022 - 07/2011
3	Neoplasms (Cancer) 01/2019 - 05/2014
3	Right Ventricular Hypertrophy 12/2018 - 08/2012
3	Hypertension (High Blood Pressure) 12/2007 - 02/2002
2	Microvascular Rarefaction 01/2020 - 04/2009
2	Heart Failure 12/2018 - 12/2007
2	Diabetes Mellitus 01/2018 - 01/2018
2	Ischemia 11/2013 - 11/2012
2	Atherosclerosis 11/2013 - 07/2012
2	Hyperglycemia 12/2008 - 07/2008
1	Wounds and Injuries (Trauma) 05/2022
1	Respiratory Tract Diseases (Respiratory Tract Disease) 12/2021
1	Starvation 01/2021
1	Malaria 01/2020
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2020
1	Thoracic Aortic Aneurysm 01/2019
1	Aortic Aneurysm (Aneurysm, Aortic) 01/2019
1	Marfan Syndrome (Marfan's Syndrome) 01/2019
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2018
1	Pain (Aches) 01/2017
1	Lung Neoplasms (Lung Cancer) 01/2016
1	Myocardial Infarction 08/2014
1	Mouth Neoplasms (Oral Cancer) 05/2014
1	Hyperthermia 05/2014
1	Melanoma (Melanoma, Malignant) 01/2014

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 07/2020 - 07/2008
5	Pharmaceutical PreparationsIBA 12/2021 - 12/2007
5	MonocrotalineIBA 01/2021 - 08/2012
4	TRPC6 Cation ChannelIBA 12/2021 - 09/2015
3	CationsIBA 01/2022 - 08/2014
3	CalciumIBA 01/2021 - 12/2008
3	Calcium-Sensing ReceptorsIBA 01/2020 - 01/2016
2	LigandsIBA 01/2022 - 12/2021
2	Silicone Elastomers (SE 30)IBA 10/2021 - 07/2020
2	Ion Channels (Ion Channel)IBA 01/2021 - 07/2011
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 07/2020 - 12/2018
2	MicroRNAs (MicroRNA)IBA 01/2020 - 01/2016
2	Stromal Interaction Molecule 2IBA 01/2020 - 01/2018
2	Therapeutic UsesIBA 01/2020 - 12/2018
2	Chloroquine (Aralen)FDA LinkGeneric 01/2020 - 11/2017
2	Transient Receptor Potential ChannelsIBA 01/2019 - 01/2018
2	TOR Serine-Threonine KinasesIBA 12/2018 - 01/2015
2	Superoxides (Superoxide)IBA 01/2018 - 02/2002
2	Superoxide DismutaseIBA 01/2018 - 07/2003
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 09/2015 - 11/2009
2	Protein Isoforms (Isoforms)IBA 01/2015 - 01/2014
2	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 08/2014 - 04/2009
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2013 - 12/2007
2	Calcium Channels (Calcium Channel)IBA 07/2013 - 06/2013
1	Nicotine FDA Link 05/2022
1	AntigensIBA 11/2021
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 11/2021
1	PolymersIBA 10/2021
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2021
1	halofuginoneIBA 01/2021
1	Sirolimus (Rapamycin)FDA Link 01/2021
1	Gap Junction alpha-5 ProteinIBA 12/2020
1	Platelet-Derived Growth FactorIBA 07/2020
1	Conditioned Culture MediaIBA 07/2020
1	Becaplermin (PDGF-BB)FDA Link 07/2020
1	tetramethylpyrazineIBA 01/2020
1	Thymidine Monophosphate (TMP)IBA 01/2020
1	Semaxinib (SU5416)IBA 01/2020
1	1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	cobinamideIBA 01/2019
1	Protein Kinases (Protein Kinase)IBA 01/2019
1	Mechanistic Target of Rapamycin Complex 1IBA 12/2018
1	Mechanistic Target of Rapamycin Complex 2IBA 12/2018
1	MTOR InhibitorsIBA 12/2018
1	Blood Glucose (Blood Sugar)IBA 01/2018
1	HexokinaseIBA 01/2018
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2018
1	Voltage-Dependent Anion ChannelsIBA 01/2018
1	Copper Transport ProteinsIBA 01/2018
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2018
1	Copper-Transporting ATPasesIBA 01/2018
1	Insulin (Novolin)FDA Link 01/2018
1	Vasodilator Agents (Vasodilators)IBA 11/2017
1	Capsaicin (Zostrix)FDA Link 01/2017
1	Adenosine Triphosphate (ATP)IBA 01/2016
1	Small Interfering RNA (siRNA)IBA 01/2016
1	TensinsIBA 01/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2015
1	Cisplatin (Platino)FDA LinkGeneric 05/2014
1	ferric oxide (iron oxide)IBA 05/2014
1	ferumoxides (Feridex)FDA Link 05/2014
1	Oxygen (Dioxygen)IBA 11/2013

Therapy/Procedure

5	Therapeutics 01/2022 - 05/2014
1	Mechanical Ventilators (Ventilator) 10/2020
1	Traditional Medicine (Folk Remedies) 01/2020
1	Radiotherapy 05/2014
1	Drug Therapy (Chemotherapy) 05/2014
1	Induced Hyperthermia (Thermotherapy) 05/2014